... converted by the enzyme 5αreductase to dihydrotestosterone in the gland The periurethral portion ofthe gland increases in size during puberty and after the age of 55 due to the growth of nonmalignant ... and Pathology The prostate is located in the pelvis and is surrounded by the rectum, the bladder, the periprostatic and dorsal vein complexes that are responsible for erectile function, andthe ... produced in the epithelial cells Both prostate epithelial cells and stromal cells express androgen receptors and depend on androgens for growth Testosterone, the major circulating androgen, is...
... which the tempo ofthe illness is altered and symptoms controlled until the patient dies of other causes These can be equivalent therapeutically from a patient standpoint if the patient has not ... death, the states model allows a distinction between cure the elimination of all cancer cells, the primary therapeutic objective when treating most cancers and cancer control, in which the tempo of ... surgically remains in the state of localized disease as long as the PSA remains undetectable The time within a state becomes a measure ofthe efficacy of an intervention, though the effect may not...
... palpable, andof these, 70% are pathologically organ-confined The downside of widespread PSA screening is the detection and treatment of cancers with such a low malignant potential that they would ... examined for the presence of cancer, andthe amount of cancer is quantified based on the length ofthe tumor within the core andthe percentage ofthe core involved ... course of antibiotics before biopsy Men with an abnormal PSA and negative biopsy are advised to undergo a repeat biopsy Each core ofthe biopsy is examined for the presence of cancer, andthe amount...
... to the extent ofthe disease within the gland, the presence or absence of capsular invasion, involvement of seminal vesicles, and extension of disease to lymph nodes Because ofthe inadequacy of ... identified solely on the basis of an abnormal PSA (T1c), those that are palpable but clinically confined to the gland (T2), and those that have extended outside the gland (T3 and T4) (Table 91-1) ... for staging, the staging system was modified to include the results of imaging studies Unfortunately, no single test has proven to indicate accurately the stage or the presence of organ-confined...
... more advanced the disease, the lower the probability of local control andthe higher the probability of systemic relapse More important is that within the categories of T1, T2, and T3 disease ... radiation therapy, or active surveillance Choice of therapy requires the consideration of several factors: the presence of symptoms, the probability that the untreated tumor will adversely affect the ... of outcomes of various forms of therapy is limited by the lack of prospective trials, referral bias, and differences in the outcomes used The primary outcomes are cancer control and treatment-related...
... radiation therapy (IMRT) to maximize the dose to the prostate and to minimize the exposure ofthe surrounding normal structures The addition of IMRT has permitted further shaping ofthe dose, ... radiation therapy The aim is to decrease the size ofthe prostate and, consequently, to reduce the exposure of normal tissues to full-dose radiation, to increase local control rates, and to decrease the ... pretreatment, the dose administered, andthe time of assessment Postradiation erectile dysfunction is related to a disruption ofthe vascular supply and not the nerve fibers Neoadjuvant hormone therapy...
... surgery and/ or radiation therapy By definition, patients have no evidence of disease on scan For these patients the central issue is whether the rise in PSA results from persistent disease in the ... undergone radiation therapy The decision to recommend radiation therapy after prostatectomy is often made on the basis ofthe pathologic findings at surgery, as imaging studies such as CT and bone scan ... estimated that 10–15% of patients had "insignificant" cancers Given the multifocality ofthe disease, a concern is the limited ability to predict pathologic findings on the basis of a needle biopsy,...
... Outcomes of Androgen Depletion The antiprostate cancer effects ofthe various androgen depletion strategies are similar, andthe clinical course is predictable: an initial response, then a period of ... quality of life Combined androgen blockade the administration of an antiandrogen plus a GnRH analogue or surgical orchiectomy—was designed to inhibit both testicular and adrenal androgens at the ... patients treated with radiation therapy and years of androgen depletion relative to radiation alone, was criticized for the poor outcomes ofthe control group Another showing a survival benefit...
... at bedtime) act by relaxing the smooth muscle ofthe bladder neck and increasing peak urinary flow rates No data show that these agents influence the progression ofthe disease Surgical approaches ... Over 5 how often past month, the have you found it difficult to postpone urination? Over the past month, how often have you had a weak urinary stream? Over the (No (1 (2 (3 (4 (5 how often past ... regardless ofthe size ofthe gland, while those with an inability to urinate, gross hematuria, recurrent infection, or bladder stones may require surgery In patients with symptoms, uroflowmetry...
... connect the USB cable between the Spartan3E and your PC Then when you turn on the power, the PC should recognize the Xilinx cable/board and install the drivers 16 Once the PC has recognized the USB ... bypass for the other chips (the xcf04s andthe xc2c64) The summary looks like this: 21 In the iMPACT screen you should now see the following window that shows the programmable chips andthe associated ... to get all the details ofthe pins correct as they’re described in the manual! The switches won’t function properly without the pullup, for example, andthe LEDs really need to have the drive...
... the HSS andthe ISIM have to show to each other that they know the secret key The S-CSCF assigned to the user takes the role ofthe authenticator, delegated from the HSS The S-CSCF uses the Diameter ... base64 encoding ofthe RAND andthe AUTN The value ofthe algorithm parameter is set to AKAv1-MD5 Figure 12.8 shows the contents ofthe WWW-Authenticate header field WWW-Authenticate: Digest realm="domain.com", ... 12.8: WWW-Authenticate header field When the terminal receives the 401 (Unauthorized) response (10) it deduces the RAND andthe AUTN from the nonce The ISIM verifies the AUTN using the SQN and its...
... further expand opportunities for cybercriminals and other threat actors to gain profit, steal information, and sabotage their targets’ operations Our 2013 forecasts: The volume of malicious and ... of deployment 10 Africa will become a new safe harbor for cybercriminals 1 The volume of malicious and high-risk Android apps will hit million in 2013 The number of malicious and high-risk Android ... Microsoft Windows Google has made improvements to the Android platform’s security App scanning in the form of Bouncer was first introduced in February and integrated into devices with the use of the...
... governance of IT and encourage realignment of those structures with the reality of a networked world (and institution) The collection then turns to the heart ofthe academy—scholarship and teaching, and ... The premise of this volume is that the spectacular success ofthe network, the persistent interconnection of billions of people, the emergence of English as the global language of commerce, and ... University of Chicago, Walter Weir ofthe University of Nebraska, and Khalil Yazdi ofthe University of Mary Washington If authors are the architects of books, then the editorial and production...
... maximum at the end ofthe day, when LHY and CCA1 are at their minimum TOC1 then either directly or indirectly stimulates the expression of LHY and CCA1, andthe cycle begins again The two MYB ... been inferred from the effects of red and far-red light on the surface potential of roots and oat (Avena) coleoptiles, where the lag between the production of Pfr andthe onset of measurable potential ... at the end of each photoperiod (called the end -of- day far-red response) Both of these responses are likely to involve perception ofthe Pfr:Ptotal ratio and occur in the low-fluence region of the...
... concerns the identification and manipulation ofthe genetic, biologic, and environmental factors in the causal pathway of cancer Education and Healthful Habits Public education on the avoidance of ... about the hazards of smoking, the features of a healthy lifestyle (including diet and exercise), use of proven cancer screening methods, and sun avoidance Smoking Cessation Tobacco smoking is the ... cancer Lung cancer and cancers ofthe larynx, oropharynx, esophagus, kidney, bladder, pancreas, and stomach are all tobacco-related The degree of smoke exposure, meaning the number of cigarettes smoked...
... 9.8% of women in the low-fat diet group compared to 12.4% of women on the standard diet In observational studies, dietary fiber lowers the risk of colonic polyps and invasive cancer ofthe colon ... for cancers ofthe breast, colon, prostate, and endometrium These cancers have their highest incidence and mortalities in western culture where fat comprises an average of 40–45% ofthe total calories ... protective effects of increasing fiber and lowering dietary fat have not been proven in the context of a prospective clinical trial The putative protective mechanisms are complex and speculative...
... gas Cancer ofthe lung, head and neck, nasal sinuses Nickel dust Cancer ofthe lung, nasal sinuses Phenacetin Cancer ofthe renal pelvis and bladder Polycyclic hydrocarbons Cancer ofthe lung, ... such as androgens, linked to prostate cancer, and estrogen, linked to breast and endometrial cancer The distinction between an initiator and promoter is sometimes arbitrary; some components of cigarette ... Burkitt's lymphoma, nasal T cell lymphoma Estrogens Cancer ofthe endometrium, liver, breast Ethyl alcohol Cancer ofthe liver, esophagus, head and neck Helicobacter pylori Gastric cancer, gastric...
... taking placebo andof per 1000 subjects per year for those taking β-carotene The ATBC and CARET results demonstrate the importance of testing chemoprevention hypotheses thoroughly before their widespread ... women taking placebo Of >16,600 women randomized and followed for a median of 5.6 years, 43 invasive colorectal cancers occurred in the hormone group and 72 in the placebo group The positive effect ... piroxicam, sulindac, and aspirin, may prevent adenoma formation or cause regression of adenomatous polyps The mechanism of action of NSAIDs is unknown, but they are presumed to work through the cyclooxygenase...
... cervical and head and neck cancer, and Helicobacter pylori is associated with gastric cancer and lymphoma Vaccines to protect against these agents may reduce the risk of their associated cancers The ... placebo After years of therapy, the incidence of prostate cancer was 18.4% in the finasteride arm and 24.8% in the placebo arm, a statistically significant difference However, the finasteride group ... infection with any ofthe four component strains (6, 11, 16, 18) The vaccine is recommended for girls and women ages 9–26 years Reduction in these HPV types could prevent >70% ofthe cervical cancers...